(See 365 Comics #49, 50, 51 and 75 for comments on volumes 1-4)
Volume 5 kicks off with a 3-part interlude that looks back roughly100 years at a situation that occurred between British missionaries and Inuit natives of Alaska that telegraphs some of the backstory for the contagion that destroyed most of the population and created animal-human hybrids in its stead. Matt Kindt (MIND MGMT) takes over art chores for the arc and I don't think you can find a more like-minded and complimentary artist to take over for Jeff Lemire. The art shift serves dual purpose to establish a different tone and feel for the flashback, where things get heavy and gruesome (as things have a tendency of winding up in Sweet Tooth).
The four chapters that follow serve to close out the Project Evergreen sub-plot that was introduced in Endagered Species. How it plays out, along with Jepperd, Gus and Dr. Singh's stories, seem quite Lost-like, jumping between tangential characters and plot reveals. The end of this two-volume arc moves along at a brisk clip (as the series generally does) only this late in the game it almost feels over-simplified as a result. It's definitely winding towards its end-game (volume 6 arrives next month), which will make or break the whole series for me. I've enjoyed the ride, but even at this stage, I'm still not quite certain my real feelings towards it. I'll most likely need to reread the run to figure that out.